Interactions between the cannabinoid and dopaminergic systems: Evidence from animal studies
Identifieur interne : 000145 ( France/Analysis ); précédent : 000144; suivant : 000146Interactions between the cannabinoid and dopaminergic systems: Evidence from animal studies
Auteurs : Marie-Anne El Khoury [France] ; Victor Gorgievski [France] ; Larissa Moutsimilli [France] ; Bruno Giros [France, Canada] ; Eleni T. Tzavara [France]Source :
- Progress in neuro-psychopharmacology & biological psychiatry [ 0278-5846 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Interaction, Cannabinoïde, Voie dopaminergique, Animal, Flexibilité intellectuelle, Fonction exécutive, Cognition, Souris knockout, Récepteur métabotropique, Récepteur glutamate, Psychose, Récepteur vanilloïde VR1, Substance toxicomanogène, Transporteur de la dopamine, Set attentionnel, Récepteur vanilloïde TRPV1.
English descriptors
- KwdEn :
Abstract
There is a prominent role of the cannabinoid system to control basal ganglia function, in respect to reward, psychomotor function and motor control. Cannabinoid dysregulations might have a pathogenetic role in dopamine- and basal ganglia related neuropsychiatric disorders, such as drug addiction, psychosis, Parkinson's disease and Huntington's disease. This review highlights interactions between cannabinoids, and dopamine, to modulate neurotransmitter release and synaptic plasticity in the context of drug addiction, psychosis and cognition. Modulating endocannabinoid function, as a plasticity based therapeutic strategy, in the above pathologies with particular focus on cannabinoid receptor type 1 (CB1 receptor) antagonists/inverse agonists, is discussed. On the basis of the existing literature and of new experimental evidence presented here, CB1 receptor antagonists might be beneficial in disease states associated with hedonic dysregulation, and with cognitive dysfunction in particular in the context of psychosis. It is suggested that this effects might be mediated via a hyperglutamatergic state through metabotropic glutamate activation. Indications for endocannabinoid catabolism inhibitors in psychiatric disorders, that might be CB1 receptor independent and might involve TRPV1 receptors, are also discussed.
Affiliations:
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Marie Curie, 9 quai St Bernard</s1><s2>75005 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>UPMC, Université Paris 06, Pathophysiology of CNS Disorders, 9 quai St Bernard</s1><s2>75005 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>75005 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Centre National de la Recherche Scientifique (CNRS) UMR7224, 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Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>UPMC, Université Paris 06, Pathophysiology of CNS Disorders, 9 quai St Bernard</s1><s2>75005 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>75005 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Centre National de la Recherche Scientifique (CNRS) UMR7224, Universite Pierre et Marie Curie, 9 quai St Bernard</s1><s2>75005 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 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wicri:level="1"><inist:fA14 i1="02"><s1>UPMC, Université Paris 06, Pathophysiology of CNS Disorders, 9 quai St Bernard</s1><s2>75005 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>75005 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Centre National de la Recherche Scientifique (CNRS) UMR7224, Universite Pierre et Marie Curie, 9 quai St Bernard</s1><s2>75005 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>75005 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Douglas Hospital Research Center, Dpt of Psychiatry McGill University</s1><s2>Montreal</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Tzavara, Eleni T" sort="Tzavara, Eleni T" uniqKey="Tzavara E" first="Eleni T." last="Tzavara">Eleni T. Tzavara</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM) UMRS-952, Universite Pierre et Marie Curie, 9 quai St Bernard</s1><s2>75005 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>UPMC, Université Paris 06, Pathophysiology of CNS Disorders, 9 quai St Bernard</s1><s2>75005 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>75005 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Centre National de la Recherche Scientifique (CNRS) UMR7224, Universite Pierre et Marie Curie, 9 quai St Bernard</s1><s2>75005 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>75005 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author></analytic><series><title level="j" type="main">Progress in neuro-psychopharmacology & biological psychiatry</title><title level="j" type="abbreviated">Prog. neuro-psychopharmacol. biol. psychiatr.</title><idno type="ISSN">0278-5846</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Progress in neuro-psychopharmacology & biological psychiatry</title><title level="j" type="abbreviated">Prog. neuro-psychopharmacol. biol. psychiatr.</title><idno type="ISSN">0278-5846</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Attentional set</term><term>Cannabinoid</term><term>Cognition</term><term>Dopaminergic pathway</term><term>Drug of abuse</term><term>Executive function</term><term>Glutamate receptor</term><term>Intellectual flexibility</term><term>Interaction</term><term>Knockout mouse</term><term>Metabotropic receptor</term><term>Psychosis</term><term>TRPV1 vanilloid receptor</term><term>VR1 vanilloid receptor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Interaction</term><term>Cannabinoïde</term><term>Voie dopaminergique</term><term>Animal</term><term>Flexibilité intellectuelle</term><term>Fonction exécutive</term><term>Cognition</term><term>Souris knockout</term><term>Récepteur métabotropique</term><term>Récepteur glutamate</term><term>Psychose</term><term>Récepteur vanilloïde VR1</term><term>Substance toxicomanogène</term><term>Transporteur de la dopamine</term><term>Set attentionnel</term><term>Récepteur vanilloïde TRPV1</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is a prominent role of the cannabinoid system to control basal ganglia function, in respect to reward, psychomotor function and motor control. Cannabinoid dysregulations might have a pathogenetic role in dopamine- and basal ganglia related neuropsychiatric disorders, such as drug addiction, psychosis, Parkinson's disease and Huntington's disease. This review highlights interactions between cannabinoids, and dopamine, to modulate neurotransmitter release and synaptic plasticity in the context of drug addiction, psychosis and cognition. Modulating endocannabinoid function, as a plasticity based therapeutic strategy, in the above pathologies with particular focus on cannabinoid receptor type 1 (CB1 receptor) antagonists/inverse agonists, is discussed. On the basis of the existing literature and of new experimental evidence presented here, CB1 receptor antagonists might be beneficial in disease states associated with hedonic dysregulation, and with cognitive dysfunction in particular in the context of psychosis. It is suggested that this effects might be mediated via a hyperglutamatergic state through metabotropic glutamate activation. Indications for endocannabinoid catabolism inhibitors in psychiatric disorders, that might be CB1 receptor independent and might involve TRPV1 receptors, are also discussed.</div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Québec</li><li>Île-de-France</li></region><settlement><li>Montréal</li><li>Paris</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="El Khoury, Marie Anne" sort="El Khoury, Marie Anne" uniqKey="El Khoury M" first="Marie-Anne" last="El Khoury">Marie-Anne El Khoury</name></region><name sortKey="El Khoury, Marie Anne" sort="El Khoury, Marie Anne" uniqKey="El Khoury M" first="Marie-Anne" last="El Khoury">Marie-Anne El Khoury</name><name sortKey="El Khoury, Marie Anne" sort="El Khoury, Marie Anne" uniqKey="El Khoury M" first="Marie-Anne" last="El Khoury">Marie-Anne El Khoury</name><name sortKey="Giros, Bruno" sort="Giros, Bruno" uniqKey="Giros B" first="Bruno" last="Giros">Bruno Giros</name><name sortKey="Giros, Bruno" sort="Giros, Bruno" uniqKey="Giros B" first="Bruno" last="Giros">Bruno Giros</name><name sortKey="Giros, Bruno" sort="Giros, Bruno" uniqKey="Giros B" first="Bruno" last="Giros">Bruno Giros</name><name sortKey="Gorgievski, Victor" sort="Gorgievski, Victor" uniqKey="Gorgievski V" first="Victor" last="Gorgievski">Victor Gorgievski</name><name sortKey="Gorgievski, Victor" sort="Gorgievski, Victor" uniqKey="Gorgievski V" first="Victor" last="Gorgievski">Victor Gorgievski</name><name sortKey="Gorgievski, Victor" sort="Gorgievski, Victor" uniqKey="Gorgievski V" first="Victor" last="Gorgievski">Victor Gorgievski</name><name sortKey="Moutsimilli, Larissa" sort="Moutsimilli, Larissa" uniqKey="Moutsimilli L" first="Larissa" last="Moutsimilli">Larissa Moutsimilli</name><name sortKey="Moutsimilli, Larissa" sort="Moutsimilli, Larissa" uniqKey="Moutsimilli L" first="Larissa" last="Moutsimilli">Larissa Moutsimilli</name><name sortKey="Moutsimilli, Larissa" sort="Moutsimilli, Larissa" uniqKey="Moutsimilli L" first="Larissa" last="Moutsimilli">Larissa Moutsimilli</name><name sortKey="Tzavara, Eleni T" sort="Tzavara, Eleni T" uniqKey="Tzavara E" first="Eleni T." last="Tzavara">Eleni T. Tzavara</name><name sortKey="Tzavara, Eleni T" sort="Tzavara, Eleni T" uniqKey="Tzavara E" first="Eleni T." last="Tzavara">Eleni T. Tzavara</name><name sortKey="Tzavara, Eleni T" sort="Tzavara, Eleni T" uniqKey="Tzavara E" first="Eleni T." last="Tzavara">Eleni T. Tzavara</name></country><country name="Canada"><region name="Québec"><name sortKey="Giros, Bruno" sort="Giros, Bruno" uniqKey="Giros B" first="Bruno" last="Giros">Bruno Giros</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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